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Real members of myPCOSteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Why Is The Doctor Percribing Me Spironolactone?

A myPCOSteam Member asked a question 💭
Hawthorne, CA

So the doctor had done a ultrasound on me on my first appointment seeing him and informed me that "it looks like my uterus lining is thick" so he prescribed me with 200mg progesterone for 10 days to thin out the lining and have my menstrual regulated. He mentioned that it should regulate my period which i havent had since age 22 and i am 33 right now. So i was excited thinking im about have my menstrual regulated again and have a chance to conceive which ive been trying the last 13 years with… read more

December 6, 2023
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A myPCOSteam Member

Hi! I would first like to comment that it's odd he took what you said during your virtual meeting as a positive sign. If you took 200mg of progesterone for 10 days, you should have bled 1-3 days afterward. If you didn't see any change in your menstrual cycle, how exactly does that show your endometrium has thinned enough? As you may know, the endometrial lining cannot be too thick or thin. If it's too thick, you may have irregular periods, lowered chances for implantation, and your risks for uterine cancer increase (Estrogen causes the lining to thicken for you to be able to conceive. Progesterone thins the lining, which should help create the environment for a baby to grow.) As for spironolactone, it is very helpful with managing the androgens. According to an article I've read, "Spironolactone acts as an anti-androgen by blocking androgen receptors, including the receptors on hair follicles, which prevents testosterone from binding and exerting its hirsutism-causing effect. Spironolactone also decreases androgen production from the ovaries and adrenal glands." I took it not too long ago to treat cystic acne caused by the high androgens. I hated the taste of it to the point of gagging, but that's besides the point. I also took minocycline. It took about 4-5 months for the cystic acne to go away. Drugs like spironolactone take a while to work. However, if you feel that his treatment doesn't make sense or isn't right for you, I think you should get a second opinion from an endocrinologist as they specialize in pcos. Best of luck to you.

(As for the constant peeing, it should get better after the first month or so. Spironolcatone is a diuretic or "water pill", so it helps get rid of excess fluid. It shouldn't have adverse effects. If you experience any side effects such as heart palpitations, dizziness, diarrhea, breast pain, blood in stools, nausea, vomiting, and etc while taking them, please contact your doctor as soon as possible and ask him to take you off the medication.)

December 8, 2023 (edited)

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